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| Major Employers | |||
| Employer | Product | Employees | Union Affiliation |
| Lufkin Industries | Oilfield Services | 1745 | AM & IBBW |
| Lufkin ISD | Public School | 1500 | |
| Pilgrim's Pride | Poultry Prepackaging | 1466 | USCW |
| Brookshire Brothers/Polk Oil | Grocery Store/Oil Distribution | 1396 | |
| Lufkin State Supported Living Center | Individual/Family Services | 1132 | |
| Memorial Healthcare System of East Texas | Medical Facility | 1119 | |
| Temple Inland | Lumber, Fiberboard, Particle Board | 554 | |
| Walmart | Retail | 525 | |
| Woodland Heights Medical Systems | Medical Facility | 500 | |
| City of Lufkin | City Government | 436 | |
| Angelina County | County Government | 400 | |
| Etech Incorporated | Telephone Solicitation | 400 | |
| Hudson ISD | Public School | 320 | |
| Diboll ISD | Public School | 278 | |
| Huntington ISD | Public School | 267 | |
| Angelina College | Community College | 261 | |
| Burke Center | Medical Services | 258 | |
| Central ISD | Public School | 225 | |
| Atkinson Candy Company | Candy Manufacturing | 216 | |
| Lockheed Martin | Aerospace & Defense | 206 | |
| Quad/Graphics | Color Comics, Ad Inserts, Printing | 197 | |